Cagrilitide | Long-Acting Amylin Analog | Research Peptide

For research use only. Not for human consumption. Not for diagnostic or therapeutic use.

Cagrilitide is a synthetic, long-acting amylin analog peptide. It is one of the most studied metabolic research compounds available today. At Global Peptides Official, we supply Cagrilitide at verified high purity, backed by third-party Janoshik lab testing and a full COA.

Cagrilitide Specs Table

What Exactly Is Cagrilitide?

Good question. Let’s keep it simple.

This peptide is a modified version of amylin. Amylin is a 37-amino-acid peptide hormone. It is naturally co-secreted with insulin from pancreatic beta cells.

So, native amylin has a very short half-life. It breaks down fast. That makes it difficult to use in research. Cagrilitide solves that.

It was developed by Novo Nordisk. The structural modifications include N-terminal acylation using a C20 fatty diacid. There is also an intramolecular disulfide bond between Cys3 and Cys8. These changes make the molecule far more stable. Therefore, it lasts much longer in research models.

Also, this peptides acts as a non-selective dual amylin and calcitonin receptor (DACRA) agonist. It targets AMY1R, AMY3R, and the calcitonin receptor (CTR). That dual action is part of what makes it interesting for metabolic research.

Finally, its half-life in research settings runs approximately 159–195 hours. That supports once-weekly dosing protocols in preclinical models.

Is Cagrilitide Lab Tested? What Purity Can I Expect?

Yes. Every batch we carry at Global Peptides Official is third-party tested by Janoshik laboratories.

Janoshik is an independent lab widely used in the research peptide space. They test via HPLC and mass spectrometry. So you get real numbers, not just label claims.

Our Cagrilitide consistently comes back at ≥99% purity. A full COA is available on request. However, we recommend always reviewing the COA before use. Purity matters in metabolic research. Lower-grade material introduces variables you do not want.

Also, our Cagrilitide is supplied as a sterile lyophilized powder. This form is stable. It is easy to reconstitute. And it ships and stores cleanly at -20°C.

How Is Cagrilitide Used in Research?

Let’s go through the main areas where Cagrilitide appears in the literature.

First, metabolic and obesity research. Cagrilitide has been studied in rodent models of high-fat diet-induced obesity. Published preclinical data shows significant reductions in body weight and food intake. Specifically, one study showed -3.4g body weight loss in wild-type cagrilintide-treated mice compared to controls.

Next, glycemic regulation studies. Researchers use it to examine postprandial glucose dynamics, glucagon suppression, and gastric emptying in pancreatic islet models.

Also, combination studies. Cagrilitide is frequently paired with GLP-1 analogs like semaglutide. The two compounds act on separate receptor populations. So, researchers study whether their combined effects are additive in appetite suppression and weight management models.

However, note that Cagrilitide is still under active clinical investigation. Phase 3 trials (REDEFINE and REIMAGINE programs) are ongoing. All preclinical and research use findings must be interpreted within that context.

Finally, pharmacokinetic studies. The long half-life and albumin-binding mechanism of Cagrilitide make it a useful tool in peptide stability and formulation research.

What Makes Cagrilitide Different From Native Amylin?

This is where the structural chemistry matters.

Native amylin degrades fast. It forms amyloid fibrils. It has a very short half-life. So, it is not practical for sustained research protocols.

Cagrilitide solves several of these problems at once. First, the disulfide bond (Cys3–Cys8) stabilizes the peptide backbone. Next, the C20 fatty diacid acylation promotes reversible albumin binding. This is the same mechanism used by semaglutide to extend its duration of action.

Therefore, Cagrilitide has a dramatically extended half-life (~180 hours vs. minutes for native amylin). Also, it shows reduced amyloid fibril formation. That improves reproducibility in lab settings.

But there is another point worth noting. Cagrilitide is a non-selective DACRA. It hits both amylin and calcitonin receptors. Native amylin is more selective. So, the research pharmacology is different. Researchers need to account for that when designing experiments.

Where Can I Buy Cagrilitide With a Verified COA?

Right here at Global Peptides Official.

We stock Cagrilitide in 5mg and 10mg vials. Each vial is lyophilized. Purity is ≥99% by Janoshik  testing. COA is available for every batch.

However, a few things to be clear about: this product is for research use only. It is not approved by the FDA. It is not for human consumption. It is not a therapeutic product. Qualified researchers and licensed laboratory professionals are the intended buyers.

So, if you are a researcher looking for a well-characterized, high-purity Cagrilitide for your metabolic, obesity, or pharmacokinetic work  you are in the right place.

Storage and Handling

• Store lyophilized powder at -20°C
• Reconstitute with sterile bacteriostatic water
• After reconstitution, store at 4°C
• Use reconstituted solution within 28–30 days
• Avoid repeated freeze-thaw cycles
• Keep away from light and moisture

Cagrilitide is sold exclusively for laboratory research purposes. This product is not intended to diagnose, treat, cure, or prevent any disease. Not for human use. Global Peptides Official complies with all applicable regulations regarding the sale of research peptides.