What exactly is SS-31?

SS-31 (Elamipretide) is a synthetic tetrapeptide. That means it’s a short chain of four amino acids. The full sequence is D-Arg–Dmt–Lys–Phe–NH₂.

It was developed by Dr. Hazel Szeto and Dr. Peter Schiller at Cornell University. “SS” stands for Szeto-Schiller. “31” is just its place in a numbered series of related compounds.

So it’s also called elamipretide, MTP-131, and Bendavia. Same compound, different names depending on the study you’re reading.

The key structural feature? It uses alternating cationic and aromatic residues. That specific design lets it bind to cardiolipin. Cardiolipin is a phospholipid found almost exclusively in the inner mitochondrial membrane.

Therefore, SS-31 concentrates inside mitochondria. That makes it a precise tool for mitochondria-focused research.

Is SS-31 (Elamipretide) tested? What does the COA show?

Yes. Every batch from Global Peptides Official is independently tested by Janoshik laboratory.

Janoshik is a well-known third-party analytical lab. Researchers trust it because it has no commercial interest in the result. The test is unbiased.

But what does 99.2% actually mean? It means less than 1% of the material is anything other than SS-31. So you’re working with a clean compound. That matters when you need reproducible results.

Also, identity confirmation via mass spectrometry confirms the molecular weight matches 639.8 g/mol. No guessing. The COA shows both purity and identity.

How should SS-31 be stored and handled in the lab?

First, keep it at −20°C for long-term storage. That’s standard for lyophilized peptides. It protects the structure and prevents degradation.

For short-term use (days to a couple weeks), 2–8°C is acceptable. However, avoid repeated freeze-thaw cycles. Each cycle introduces moisture and stresses the peptide bonds.

Next, protect it from light. UV exposure can affect aromatic residues. The dimethyltyrosine (Dmt) residue in SS-31 is particularly sensitive.

Finally, when reconstituting: use sterile water or your buffer of choice. Reconstitute only what you need. Store unused lyophilized material back at −20°C. Once in solution, use it promptly or aliquot and freeze.

SS-31 is shipped as a white lyophilized powder. It’s stable during transit at ambient temperature for a few days, but store it cold immediately upon arrival.

What does the published research on SS-31 actually show?

SS-31 (Elamipretide) has one of the stronger research profiles in the mitochondria-targeting peptide space. Here’s a quick map of where the data comes from:

Cardiolipin binding: SS-31 binds cardiolipin on the inner mitochondrial membrane. Studies show this stabilizes the membrane and supports cristae structure.

Ischemia-reperfusion models: Multiple in vivo animal studies examined SS-31 in kidney and cardiac ischemia-reperfusion injury. The compound was studied for its effects on mitochondrial morphology and ATP recovery.

Neuroscience models: Research in rodent models looked at SS-31’s effect on mitochondrial function in hippocampal tissue and in experimental glaucoma models.

Clinical trials: SS-31 (as elamipretide) advanced into Phase 2 and Phase 3 human trials. The primary indications were mitochondrial myopathy and cardiovascular/kidney disease. It received orphan drug designation from both the FDA and the European Medicines Agency for mitochondrial myopathy.

However, Phase 3 trial expectations in mitochondrial myopathy were not met as of 2020. Research in other areas continued. So the compound remains highly active in pre-clinical and translational research.

Also notable: SS-31 is one of the only peptides in this class with human clinical data available — which makes it a reference compound for new mitochondria-targeted research.

Why buy SS-31 from Global Peptides Official?

A few practical reasons researchers come back:

Independent COA: Janoshik testing. Not in-house. Not a supplier certificate. An actual independent analytical lab result. You can verify it.

Consistent batch quality: 99.2%+ purity means your results aren’t contaminated by unknown impurities. That matters if you’re comparing across experiments.

Correct form: Lyophilized powder is the correct research form. Stable, precise, easy to reconstitute to your exact target concentration.

Transparent sourcing: globalpeptidesofficial.com lists full product specs, sequence, formula, and COA. No vague claims. No missing data.

Also, ordering is straightforward. No minimum orders. Reliable shipping. SS-31 is a compound where purity matters. A cheap batch with unknown impurities wastes research time. That’s a much bigger cost than paying for verified quality upfront.